Intravenous Iron Sucrose and Ferric Carboxymaltose (FCM) Versus Oral Iron in the Treatment of Postpartum Iron Deficiency Anaemia

Objectives To evaluate the safety and efficacy of intravenous FCM& ferrous sucrose with oral iron in postpartum anaemic women. Study design Random, prospective, interventional Material and Methods The study was conducted in the department of Obstetrics and Gynaecology, J. N. Medical College, AMU, Aligarh. A total of 90 postpartum anaemic women with haemoglobin less than 10gm were assigned randomly to receive inj Ferric Carboxymaltose, oral iron or inj sucrose. Changes in haemoglobin and ferrritin level were measured and analyzed among the groups using ANOVA and paired t test. Results A statistically significant increase in Haemoglobin and ferritin level was observed in all the three groups but maximum increase was observed in inj FCM group followed by inj Sucrose and Oral iron group. Mean increase in Haemoglobin in inj Ferric Carboxymaltose group was 2.157.475 gm/dl followed by inj sucrose 1.221.576 gm/dl and oral iron 0.609.237 gm/dl at 2nd week. At 6th week increase in Haemoglobin were 4.737.994gm/dl, 3.478.799 gm/dl and 2.881.752 gm/dl respectively in inj Ferric Carboxymaltose, inj Sucrose, oral iron. Mean increase in serum ferritin were also significant in all the three groups both at 2nd and 6th weeks, but maximum increase was seen in inj FCM. Mean increase in serum ferritin level at 2nd weeks were 184.48351.746 /l, 93.27526.972/l& 2.2313.466/dl and at 6th week were 150.22341.927/l, 75.48925.586 /l and 31.9407.177/dl respectively for inj Ferric Carboxymaltose, inj sucrose and oral iron. Conclusion Haemoglobin and serum ferritin level increases fastest with Inj. Ferric Carboxymaltose followed by inj sucrose and oral iron.