A Comparative Evaluation of Propofol, Etomidate and Admixture of Propofol - Etomidate for Induction During General Anaesthesia

Background Propofol and Etomidate are non barbiturate inducing agents. These drugs have different induction characteristics and recovery profile. Propofol causes pain at injection site, hypotension but has clear headed recovery whereas Etomidate is cardiostable but can cause myoclonus. Propofol& Etomidate group, both used to decrease side effects. Objective our study we compare Propofol, Etomidate and admixture of Propofol - Etomidate on induction charcteristic i. e loss of eyelash reflex, pain at injection site, myoclonus, hemodynamic parameters and recovery profile. Methods Total no. of patients in our study was 90 with ASA grade I and II, age 18-55 years included for surgical procedure under general anesthesia were randomly divided into three groups of 30 patient each. Patients in group -I was induced with inj. Propofol (3mg/kg) i. v and patient of group -II were induced with inj. Etomidate (0.3 mg/kg) i. v and patients of group -III were induced with Combination of inj. Propofol and inj. Etomidate in the ratio of 11 by volume. Onset time i. e time to disappearance of eyelash reflex, pain at injection site and myoclonus, were noted. Continuous hemodynamic monitoring i. e HR, SBP, DBP, MAP and recovery profile was done. All the result were tabulated and statistically analysed. Result In patients of admixture Propofol-Etomidate Group, loss of eye lash reflex are earlier than Propofol and Etomidate group. In Propofol group have pain at injection site and patient in Etomidte group have some incidence of myoclonus. Conclusion Admixture of Propofol-Etomidate is hemodynamically more stable with less side effect and early recovery.