Synthesis, Characterisation and its Anti Bacterial Activity of Dalfampridine Genotoxic Impurity 4-Amino Pyridine N-Oxide
Journal: International Journal of Science and Research (IJSR) (Vol.7, No. 5)Publication Date: 2018-05-05
Authors : Mythili A; Vijayabaskaran M; Yogesh D B;
Page : 13-16
Keywords : Dalfampridine; Genotoxic impurities; N Oxidation; Nitration; Reduction; LC-MS; 1H NMR; Melting point; Anti bacterial activity;
Abstract
Objective 4-Aminopyridines and its impurities are important intermediates for chemicals, pharmaceuticals and agrochemical industry, antineoplastic, anticoagulant, anti-inflammatory [1]. Dalfampridine used for the treatment of multiple sclerosis so, the drug availability in the finished dosage form is very important. In the present study we evaluated antibacterial activity of synthesized 4- amino pyridine n- oxide by using agar cup method. Methods The serially diluted antibacterial test solution three doses of synthesized 4- amino pyridine n- oxide (50g/ml, 75g/ml and 100g/ml) were added in the cups and all the plates stood incubated for 24 hours at 370C. The zone of inhibition was measured and compared with gentamycin as a positive control. Results The synthesized 4- amino pyridine n- oxide (100g/ml) was found to be effective and it exhibited substantial antibacterial activity against its direction of Escherichia-coli Pseudomonas-aeruginosa Bacillus-subtilis Staphylococcus-aureus which activity is lesser than standard. Whereas100g/ml dose showed higher anti bacterial activity with more zone of inhibition than 75g/ml and 50g/ml dose. Conclusions The results proposed 100g/ml of synthesized 4- amino pyridine n- oxide showed significant antibacterial activity but less activity than standard drug gentamycin.
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