Synthesis and Antibacterial Activity Screening of New Trimethoprim Derivatives Containing Bis Cyclic Imides

The present work involved synthesis of new trimethoprim derivatives containing bis cyclic imides. Synthesis of the new derivatives containing maleimide, citraconimide, succinimide, phthalimide and tetrachloro phthalimide cycles was performed by reaction of trimethoprim with cyclic anhydrides producing bisamic acids which inturn were dehydrated to the corresponding bis cyclic imides by fusion method, while synthesis of trimethoprim linked to bis 1, 8- naphthalimides was made by direct fusion of trimethoprim with 1, 8- naphthalic anhydride in glacial acetic acid. The new derivatives were characterized on the basis of their FTIR, 1HNMR and 13C-NMR spectra and the results of their antibacterial activity screening showed that they exhibit good antibacterial activity