Effect of the Aqueous Extracts of Grewiavenusta Leaves on Poloxamer 407-Induced Hyperlipidemic Rats

Hyperlipidemia is considered to be one of the greatest risk contributing to the prevalence and severity of cardiovascular diseases. The present study was taken to evaluate the effect of the aqueous leaf extract of Grewia venusta on poloxamer 407-induced hyperlipidemic rats. The poloxamer 407 (P407) was administered using a single dose of 500mg/kg body weight which induced hyperlipidemia after 24 hours. Oral administration of extract, at dose of 200mg/kg body weight in rats, inhibited serum total cholesterol, triacyglycerides, low density lipoprotein, very low density lipoprotein and increased high density lipoprotein levels as compared to the Group IV treated with the standard drug (atorvastatin). The Results were expressed as meanSEM by the statistical analysis-SPSS application 20.0 i. e one way ANOVA. The meanSEM of measured hyperlipidemia induced by poloxamer 407as 198.024.2 mg/dl for TAG, 247.430.3 mg/dl for TC. The plant aqueous extract decrease total cholesterol by 44.75 % (p