Formulation&Evaluation of Mouth Dissolving Tablet of Levocetrizine Dihydrochloride

The purpose of the present study was formulation& evaluation of mouth dissolving tablet of levocetrizine dihydrochloride. Orodispersible tablets are those that dissolve or disintegrate quickly in the oral cavity, resulting in solution or suspension. This is a third generation H1 receptor antagonist used as antihistaminic and anti allergic drug. The low oral bioavailability of levocetirizine dihydrochloride due to its high first pass metabolism, led to the formulation development of fast dissolving tablets that disintegrate with-in seconds in oral cavity. The tablet was prepared using Crospovidone as super disintegrant and the optimized its concentration. The Veegum was used to mask the bitter taste of drug. Direct compression method was used for the preparation of mouth dissolving tablet. Total nine formulations were prepared, to formulate a optimized mouth dissolving tablet. three formulations F1, F 2, and F9 were prepared using drug and Veegum 11, 15 and 12 in ratio respectively. The taste evaluation results showed that F9 has the good promising taste masking properties for bitterness in drug. The remaining five formulations F3, F4, F5, F6, F7 and F8 were prepared for the optimization of concentration of superdisintegrant (Crospovidone) by taking it in 2.0 %, 3.0 %, 3.5 %, 4.0 %, 4.5 %, and 5.0 % concentration respectively and the concentration of Veegum was same in all five formulations. The percent levocetirizine dihydrochloride released form mouth dissolving tablet in formulation F3 was found to be 6.28 0.93 (minimum) and F9 was found to be 91.86 1.52 (maximum) after 10 minutes. At the same time formulation F8 released 91.57 0.74 which is very closed to formulation F9 and be said almost equal. So it was concluded that F8 was the optimized formulation contained drug and veegum in 12 ratio, pearlitol and M. C. C in 13 ratio and 5.0 % crospovidone with all other excipients which are common for all formulation.