Effect of Vitamin C and Dialium guineense Fruit Pulp Activity on HO-1, Insulin Secretion and Ace in Experimental Diabetes

The study was targeted at evaluating the modulatory effect of aqueous fruit pulp of Dialium guineense on hemeoxygenase, insulin, angiotensin converting enzyme (ACE) and possible hypoglycemia in streptozotocin-induced diabetic rats. Twenty four male Wistar rats were randomly divided into four groups control, diabetic control (Dm), diabetic + 300 mg/kg body weight Dialium guineese (Dm+ DG) and diabetic + 500 mg/kg Vitamin C (Dm +Vit. C). Animals were made diabetic by injecting a single dose of 55 mg/kg streptozotocin intraperitoneally. Dialium and Vitamin C were administered orally for three weeks. Result showed significant (p