Bacterial Pathogens and Antibacterial Susceptibility Pattern of Isolates from Blood Culture - A Retrospective Study

Introduction Now a days in ICU setup bacteremia is the important factor of mortality and morbidity. Bacteremia is defined as the presence of bacteria in the blood circulation, bacterial colonization of the blood stream is not usually fatal. Another important terminology is Transient bacteremia which is observer in several physiological conditions without any obvious clinical manifestations, The detection of pathogen on culture media in a patient's blood has a considerable diagnostic and prognostic importance. That's why Blood cultures provide essential information for the evaluation of a several diseases like endocarditis, pneumonia, pyrexia of unknown origin and particularly, in patients with suspected septicemia. Blood stream Infections are a major cause of morbidity and mortality worldwide. Aim and Objective The aim of the present study was to determine the distribution of pathogens and Blood stream infection, Septicemia, Antibiogram, Resistance. Materials and Methods A total of 300 blood specimens from patients were received from various intensive care units in Mrinmay Diagnostic Laboratory India, were cultured by standard microbiological procedures using Bactec for the isolation of pathogens. The isolates were subjected to antimicrobial susceptibility assay to investigate the resistance pattern of isolates by disc diffusion method and the reports were analyzed retrospectively over the period of three years. Discussion In the present study we observed the prevalence of Gram negative bacillus was higher than Gram positive bacteria isolated in our study. In the present, study E coli sp. showed higher resistance rate against cefixime, septran, ampicillin and ciprofloxacin. In this study we observed slightly higher rate of sensitivity against cephalosporin with betalactum followed by carbapenam group by all the gram negative bacterial pathogens isolated from blood culture. Conclusion The present study gives an idea of the current state of etiological agents of blood stream infections and their susceptibility pattern in private hospital.