Evaluation of the Use of Green Tea Extract and Vitamin C on Lung, Brain and Testis of Rats Exposed to Fenitrothion Toxicity

Organophosphorus pesticides like Fenitrothion (FNT) are inevitably found in the environment. The common involving pathway green tea extract (GTE), ascorbic acid (Vit. C) and FNT share is oxidative stress and pathological alterations in vital organs. Therefore, we conducted this study to find the possible neutralizing or synergistic effects of FNT oxidative stress and pathological alterations responses in FNT induced toxicity by daily administrated dose of GTE and Vit. C. The experiment was conducted for six weeks. Four groups containing six male albino rats each were selected. The animals were sacrificed at the end of treatment period, then lung, brain and testes were isolated for assess tissues antioxidant enzymes and histopathology purpose. Rats in FNT group exhibit significant increase of oxidative stress (OS) marker malondialdehyde (MDA) and decrease in the values of superoxide dismutase (SOD), total glutathione (GSH), catalase (CAT) and total antioxidant capacity (TAC) compared to control one in tissues. GTE and Vit. C treated groups showed decreased in the values of MDA and improved the values of SOD, GSH, CAT toward the control values in tissues although the treatment could not normalize it. While TAC level showed a significant increase with fenitrothion plus vitamin C and the fenitrothion plus green tea treated groups compared to the FNT group (p