GENDER PECULIARITIES OF METABOLIC SYNDROME AND ITS BASIC CRITERIA IN CHILDREN
Journal: Lviv Medical Journal (Львівський медичний часопис / Acta Medica Leopoliensia) (Vol.20, No. 2)Publication Date: 2014-09-01
- GENDER PECULIARITIES OF METABOLIC SYNDROME AND ITS BASIC CRITERIA IN CHILDREN
- Metabolic Syndrome in Basic Research: How to Study It
- COMPARATIVE EVALUATION OF DIAGNOSTIC CRITERIA FOR METABOLIC SYNDROME IN OVERWEIGHT/OBESE ADULT PATIENTS
- GENDER FEATURES OF IMMUNE DISORDERS IN METABOLIC SYNDROME
- Peculiarities of the course of benign uterine disease in women of childbearing age with metabolic syndrome
Abstract
Aim. To study gender peculiarities of metabolic syndrome and its diagnostic criteria in children. Methods. Out of a total of 1520 children, 90 children (41 girls and 49 boys) with metabolic syndrome aged from 9 to 18 years were selected; in the study group, anthropometry data, blood pressure, cholesterol, high density cholesterol, low density cholesterol, very low density cholesterol, nonhigh-density cholesterol, triglycerides, fasting glucose and insulin, index HOMA-IR tests were taken. Metabolic syndrome was diagnosed according to International Diabetic Federation ñonsensus (2007): abdomen obesity (waist circumference more than 90-th percentile), arterial hypertension (blood pressure ? 130/85 mm Hg), hyperglycemia (?5,6 mmol/l), hypertriglyceridemia (?1,7 mmol/l), high density cholesterol (?1,03 mmol/l and 1,29 mmol/l in girls over 16 years). Results. Gender determination of metabolic syndrome in children was not found (h=0,520). Abdomen obesity was diagnosed in all children with metabolic syndrome. In generally obese girls, abdomen obesity was diagnosed 1,8 times more often than in overweight girls; in generally obese boys, abdomen obesity was diagnosed 1,6 times more often than in overweight boys (p1=1,0; p2=1,0; respectively). Arterial hypertension in boys (61,2%) was diagnosed 1,1 times more often than in girls (53,7%; p=0,729). High blood insulin level was estimated in 20(57,6%) girls and 15(41,6%) boys; the difference amounted to 15,5% (p=0,536). Insulin resistance according to HOMA-IR was diagnosed 1,5 times more often in girls (48,5%) than in boys (33,3%; p=0,508). In boys, hyperglycemia was found 9% more frequently than in girls (p=0,419). Dyslipidemia with high level of triglycerides was diagnosed 1,6 times more often in boys (22,2%) than in girls (13,9%; p=0,572); dyslipidemia with decreased level of high density cholesterol was estimated equally in girls (36,1%), and in boys (32,6%;p=0,827). The most frequently diagnosed criteria in metabolic syndrome structure were (in descending order): in girls - abdomen obesity → hyperinsulinemia → arterial hypertension → insulin resistance → decreased level of blood high density cholesterol → hyperglycemia → high level of blood triglycerides; in boys - abdomen obesity → arterial hypertension → hyperinsulinemia → insulin resistance → decreased level of blood high density cholesterol → hyperglycemia → high level of blood triglycerides. Summary. Gender difference in metabolic syndrome frequency was not found. Gender peculiarities of metabolic syndrome structure were detected. Keywords: metabolic syndrome, diagnostic criteria, gender peculiarities
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