The Efficiency of Mitochondria-Targeted Curcumin in Reducing Thyroid Mitochondrial Oxidative Damage

Mitochondria are the crucial site for the cellular energy production. The antioxidant has less therapeutic success to overcome mitochondrial toxicity produced by oxidative stress due to mitochondrial inability in accepting antioxidant. In the present investigation, we synthesized selective mitochondrial targeted curcumin for easy transport to mitochondria of the thyroid gland. Our observation shows the strong antioxidant effect of mitochondrial targeted curcumin against lipid peroxidation and mitochondrial transition induced by Escherichia coli. Mitochondria-targeted curcumin significantly improved endogenous glutathione level in the mitochondria, its protect the motochondrial defense system against oxidative damage. Thus it is concluded that mitochondria-targeted curcumin protects mitochondria against E. coli toxicity of thyroid gland, By lowering the oxidative damage, increasing the level of reduced glutathione and preserving the mitochondrial integrity