Comparative Study on Anti Diabetic Property of Syzyium cumini, Aegle marmelos and Cocos nucifera through in vitro and in vivo Condition

The aim of the present study was to investigate presence of antidiabetic activity in plant extracts like Syzyium cumini, Aegle marmelos and Cocos nucifera using a solvent like methanol and aqueous. In preliminary phytochemical analysis and Paper Chromotography, different types of phytocompounds like alkaloids, flavonoids, phenols, glycosides and saponins were present, which it had been concluded that there is rich in phyto compounds for the antidiabetic activity which is highly responsible for regulating the pancreatic hormone for the synthesis of insulin. In the in vitro antidiabetic analysis, among all the three plant extracts, aqueous extract of Cocos nucifera have high sugar reducing capacity. Aqueous extract of Cocos nucifera were taken for HPLC analysis and antioxidant activity. HPLC analysis of Cocos nucifera resulted in attaining a sharp peak with retention time of 1.983. It was closely related to stevioside compounds. Analysis of antioxidant activity in Cocos nucifera shows 69.8 % of reduction in DPPH free radicals for 100g/ml. Aqueous extract of Cocos nucifera were further taken for in vivo study. The mice were made diabetic by intraperitoneal administration of 150mg/kg of alloxan. Finally, blood sugar reduces from 408mg/dl to 88 mg/dl when treated with endocarpic extract of coconut.