Evaluation of Antidiabetic Potential of a Novel Formulation from Prophetic Medicine in Streptozotocin-Induced Diabetic Balb/C Mice

Diabetes is a common, chronic and expensive disease that is threatening the health of generations of people all around the world. Diabetes mellitus is a disorder that affects the bodys ability to make or use insulin and it remains an incurable disorder in spite of intense research. Prophetic Medicine is the total authentic Hadith narrated by the Prophet (peace be upon him), which carries incredible values for the administration of diabetes. The present study aimed to develop a new formulation from Prophetic Medicine and to evaluate its therapeutic potential for the effective use in diabetes for avoiding major adverse effects in animal model. Towards this aim, diabetes was induced to Balb/c mice with the injection of streptozotocin (160 mg/kg). The mice were treated with the formulation of Prophetic medicine (PMFD) at the doses of 200, 400, 600 mg/kg and metformin at dose of 200 mg/kg orally. The glucose levels were measured on first day for 3 hours, second and third day for 2 hours and 2 weeks before and after treatment with the PMFD. Non-diabetic mice were used as a negative control and diabetic mice without treatment was used as a positive control. The formulation (PMFD) at the dose of 200, 400 and 600 mg/kg shows significant reduction in post-prandial plasma glucose level and body weight, whereas metformin of 200 kg/mg shows significant reduction of glucose level on second and third day. Thus, the present formulation of Prophetic medicine can be recommended for the prevention and treatment of diabetes. This data can support for biomedical research efforts that can lead to prevention, treatment and possibly even cures for diabetes.