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Improved Process for the Preparation of Halo Substituted Mannich Bases of Substituted Benzimidazoles

Journal: International Journal of Science and Research (IJSR) (Vol.6, No. 3)

Publication Date:

Authors : ; ; ;

Page : 1867-1874

Keywords : Benzimidazoles; Antimicrobial activity; Anti-fungal activity; mannich base; secondary amine;

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Abstract

Mannich bases are the end products of mannich reaction and are known as beta amino ketone carrying compounds. Mannich reaction is a carbon carbon bond forming nucleophilic addition reaction which helps in synthesizing N-methyl derivatives and many other drug molecules. Mannich base derivatives of benzimidazoles possess many pharmacological properties such as anti-oxidant, anti-inflammatory, anticancer, antiviral, anthelmintic and play an important role in medical field. As these drugs are clinically useful in treatment of microbial infections and exhibit other therapeutic activities also, so this encouraged the development of more potent, novel and clinically significant compounds.

Last modified: 2021-06-30 18:07:59