The Concentration of Adrenomedullin in Obese Subjects with and without Diabetes Compared with Healthy Control

Adrenomedullin is a potent vasodilator and antioxidative peptide. Adrenomedullin was found currently to be released by adipose tissue and associated with many diseases. This study done to investigate the association between adrenomedullin and obesity in subjects with or without diabetes. The study included 25 obese type II diabetes women, 25 obese women and 30 healthy women who attended to outpatient clinic at the department of endocrine, Al-Kindy hospital during the period between 2014-2016. Evaluation the concentration of serum adrenomedullin, Insulin, Glucagon by immunoassay kits. All participants were subjects to anthropometric measurements included body mass index. the result of this study has shown highly significant differences in the mean of BMI, serum adrenomedullin, insulin, glucagon and glucose in diabetic obese women group than control group (pless than0.001). Marked increase in serum adrenomedullin, insulin and glucose in diabetic obese women than obese women group (pless than0.001). from this study we can conclude that adrenomedullin may play a role in diabetic obese and obese subjects since all patients have highly significant elevation in serum adrenomedullin level.