Role of Mannose Binding Lectin and their associated Srine Protease in innate immunity
Journal: International Journal of Science and Research (IJSR) (Vol.6, No. 4)Publication Date: 2017-04-05
Authors : Pankaj Kumar Patel; Bavita Kohli; Krishnan Hajela;
Page : 620-625
Keywords : Mannose binding Lectin; Complement pathway; Pentraxin; Lectin pathway; MASP;
Abstract
Mannose binding Lectin (MBL) is a key pattern recognition receptor molecule, found in invertebrates to higher vertebrates, MBL initiates various immune and immunomodulatory responses on binding with the pathogen associated molecular patterns (PAMPs). MBL recognizes a wide variety of viruses, bacteria, protozoa, fungi and cell debris opsonizing and clearing them either by opsonophagocytosis or activating complement pathway through MASP-1/2 mediated cleavage of complement components C4 and C2, thus generating the C3 convertase C4bC2b. A new insight on the responses, their mechanism and role of MBL associated serine proteases are discussed in the review.
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