Effect of Coriandrumsativum Leaves Aqueous Extract on Structure and Function of Kidney in Male Albino Mice

Coriandrum sativum leaves is used in folk medicine to treat several diseases such as digestive system disorder, diabetes, and hyperlipidemia. This study was designed to investigate the effect of aqueous extract of Coriandrum sativum on the structure and function of kidney, 30 males of white Swiss mice Mus musculus were divided randomly to three groups with 10 mice in each group. Animals of first group (control group) had been given orally 0.1 ml of tap water, animals in the second group had been treated orally with 0.1 of single dose (125 mg/Kg b. w. /day) of C. sativum leaves extract and animals in the third group has been treated orally with 0.1 ml (250mg/Kg. b. w. /day) of the same extract for 30 days. At the end of experiment, the animals had been scarified and kidney were removed and kept for histological sectioning. The data of bodys weight, organs weight, uric acid and creatinine were measured. The results of the present study showed that there was no significant difference (Pgreater than0.05) in the bodys weight between the control and treated groups, as well as the kidney unchanged in its weight in animals treated with (125 mg/Kg/ b. w. ), while there was significant reduction (P0.05) in these parameters. Moreover the treatmeant with aqueous extract of C. sativum leaves extract at dose 250 mg caused abnormal histopathological changes in kidney tissue represented by degeneration in convoluted tubules epithelium, conjestion and glomerular atrophy, while the treatment with extract at dose 125 mg caused slightly changes in kidney tissue. According to above results the daily administration of Coriandrum sativum leaves extract induced a huge damage in the structure and functions of kidney.