Association of hyperuricemia with Obesity and Metabolic Co-Morbidities among Post-Menopausal Egyptian Women

Background Obesity is a global public health problem and is associated with cardio-metabolic diseases and hyperuricemia. Thus the aim of our study was to evaluate the role of serum uric acid as a marker of cardiovascular risk in screening of obesity-related metabolic comorbidities among Egyptian women according to menopausal status. Methods this a cross-sectional study included 72 pre-menopausal women and 128 post-menopausal women who were stratified according to BMI into three subgroup. Serum uric acid was measured. Fat mass (FM) were evaluated by Dual-energy X-ray absorptiometry (DEXA). Results there were significantly higher values of serum uric acid in post-menopausal women compared to pre- menopausal women, in post-menopausal women, serum uric acid levels were higher in obese compared to overweight as well as lean women, In post-menopausal women, there were significantly positive correlations between serum uric acid and fasting plasma glucose, waist circumference as well as triglycerides. Also, stepwise linear regression analysis showed that serum uric acid levels were independently correlated with systolic blood pressure, triglycerides, HbA1c and FM. Conclusion serum uric acid increased in post-menopausal women and associated with cardiovascular and metabolic diseases as well as obesity indices among Egyptian post-menopausal women.