Effect of Mercuric Chloride on Biochemical and Hematological Parameters in Male Albino Mice

This study was designed to investigate the effect of inorganic mercury (mercuric chloride) on biochemical, hematological parameters, and examining the histological changes in liver, and kidney tissues in male albino mice as a laboratory animal Model. The animals used for the sub-chronic study for mercuric chloride received 1/100 th, 1/50th, 1/20th and 1/10th of the calculated LD50 which were equivalent to 0.25, 0.5, 1.25, and 2.5 mg /kg respectively. At four concentrations, levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), urea and creatinine were high signicantly increase in mice treated with HgCl2 compared with control group. Whereas, the parameters cholesterol, glutathione (GSH), total protein, hemoglobin (Hb), red blood cells (RBC), and white blood cells (WBC) were significantly decrease in examined samples for animals treated with HgCl2 as compared with control group. It can be concluded that the altered biochemical and hematological parameters can be used as efcient bioindicators on the toxicity of mercury. Also, Mercuric chloride induced various histological alterations in liver, and kidney of mice.