Study on Anti-Inflammatory Effect of Baclofen in Albino Rats

INTRODUCTION Inflammation is a response to any noxious stimuli such as physical, chemical, immunological or infection, which produces cellular damage. Inflammation is characterized by the classic signs of rubor, calor, tumor, dolor, and functio laesa. Baclofen is a selective GABA- B agonist. Diclofenac is an NSAID acts by inhibiting cyclooxygenase enzyme. Baclofen is known to interfere with the functions of pro inflammatory chemokine receptors In this present study, baclofen was evaluated for its anti-inflammatory activity in acute inflammation. AIM To evaluate the anti-inflammatory activity of baclofen in adult albino male rats. METHODS Eighteen adult male albino rats weighing about 150-200gms were used for this study. They were divided into 3 groups of 6 rats in each group I control normal feed and water group II standard normal feed and water and received diclofenac 10 mg/kg orally and group III received normal feed and water and baclofen 8 mg/kg orally. Carrageenan was used to induce edema in mice and anti-inflammatory effect was evaluated using mercury plethysmography RESULTS There was a statistically significant anti-inflammatory activity with Baclofen comparable to Diclofenac, after three hours. The percentage inhibition of edema was 64 % with diclofenec (group II) and 56.5 % with baclofen (Group III). CONCLUSION Study showed that baclofen has significant anti-inflammatory activity in acute inflammatory animal model.