Correlation between AMH and TSH Serum Levels in PCOs and non-PCOs Sudanese Infertile Females

Background Hypothyroidism and hyperthyroidism have been associated with altered ovarian function, menstrual irregularities, subfertility and higher (recurrent) miscarriage rates suggesting that thyroid hormone affects female reproductive organ [1]. Anti-Mllerian hormone (AMH) is suggested as an important marker for ovarian reserve and in diagnosis of women with polycystic ovary disease PCOs [2]. Increase number of couples facing problems with fertility and increase prevalence of thyroid diseases made this study important to be conducted. The main objective of this study was to assess the relation between serum levels of AMH and TSH in PCOs and non-PCOs Sudanese infertile females, and to assess relation between AMH levels and presence of PCOs. Methodology Retrospective cross-sectional study was conducted from December 2016 to April 2017. Ninety seven women were recruited from the infertility outpatient clinic with different problems of infertility (primary and secondary). Forty five patients (46.4 %) of them have PCOS in different levels of severity, Rotterdam 2003 criteria were used on clinical evaluation of PCOs, six patients (6.2 %) have irregular cycle and three patient (3.1 %) have ammonehrea, 43 patients were non- PCOs. Serum AMH and TSH levels were measured by enzyme linked immune sorbent assay (ELISA). Results TSH and AMH serum levels were measured for all patients involved in this study. AMH mean 5.35 7.34 ng/ml, TSH mean 1.60 1.22 mIU/ml. A cutoff value of more than 2.5 mIU/ml for TSH were used to indicate hypothyroidism [11]. We found there was a significant negative correlation between normal AMH levels (1.2-3.0 ng /ml) and TSH levels less than2.5 mIU/ml, P-value - 0.002, a significant positive correlation between low AMH levels (less than1.2 ng/ml) and TSH levels less than 2.5 mIU/ml, P-value 0.003. No significant differences were found in other groups and parameters correlation. AMH results was significantly increased in PCOS patients group (8.86 9.07 ng/ml) when compared with non- PCOS group (2.61 3.48 ng/ml), P-value = 0.003. Conclusion Current study conclude that AMH levels had no relation to TSH serum levels in PCOs and non-PCOs groups Also we found that AMH levels were higher in patients with PCOs than those non-PCOs.