Synthesis and Reactions of 3- Cyano 4, 6- Diphenyl (2-Substituted)-Pyridine Likely to Possess Antimicrobial Activity
Journal: International Journal of Science and Research (IJSR) (Vol.6, No. 5)Publication Date: 2017-05-05
Authors : Amal F. Seliem;
Page : 1243-1248
Keywords : Antimicrobial Activity; Cyano; Diphenyl; Pyridine;
Abstract
Heterocycles containing pyridine moiety are representatives of a major structure type in medicinal chemistry and agriculture. Reaction of 2-chloro-4, 6-diphenylpyridine-3-carbonitrile 2 with each of hydrazine hydrate, hydroxylamine and anthranilic acid afforded the corresponding pyrazolo, isoxazolo and quinazolino pyridine derivatives 3, 4 and 5 respectively. While on alkylation of 2-mercapto-4, 6-diphenyl pyridine -3-carbonitrile 7 with each of ethyl chloroacetate and phenacyl bromide followed by cyclisation in presence of NaOH gave the corresponding 4, 6-diphenyl pyridine thienopyridine derivatives 9 and 12. Diazotization of ethyl 3-amino-4, 6-diphenylylthio [2, 3-b]pyridine-2-carboxylate 9 followed by reaction with each of thiourea, guanidine carbonate and hydroxylamine hydrochloride gave the corresponding thienopyridine derivatives 15, 16 and 17 respectively. The biological activity of some newly synthesized compounds has been discussed.
Other Latest Articles
- Correlation between Renal Function Tests and Thyroid Hormones in Sudanese Patients with Hypo- and Hyperthyroidism
- Application of Mamdani Fuzzy Inference System for Runoff Prediction
- An Approach for Situation Aware IOT Service based on SOA
- Predication of Students Performance Using Data Mining
- Performance Analysis of AODV and AOMDV Routing Protocols for Reducing the Energy Consumption in MANET
Last modified: 2021-06-30 18:55:25