Assessment of Liver Function Tests on Malaria Patients

Background Malaria is one of the most common widespread infectious diseases in the tropical developing countries. It affects nearly 300-500 million cases every year with mortality rate of 1.2-2.7 million deaths per year. The aim of this study to evaluate the effect of plasmodium falciparum on liver function tests on malaria patients. Methodology Cross sectional study was conducted in Sudan- Khartoum state from December 2016 to April 2017. A total of 150 adult Sudanese subjects varying in age (more than 18 years) and gender divided into two groups, 120 malaria patients and 30 healthy control subjects (C). The malaria group divided into four subgroups according to parasitemia which are M1, M2, M3, and M4 each subgroup contain 30 patients. Thick and thin blood film were done and all biochemical parameters Total protein, Albumin, Globulins, Total bilirubin, Direct bilirubin, Indirect bilirubin, AST (aspartate transaminase), ALT (alanine transaminase)& ALP (alkaline phosphatase) were analyzed by cobas integra 400 plus analyzer. Statistical analysis was done by, science SPSS Software version (16). Results In this study we found that meanSD values of ALT iu/l in C (16 5.7), M1 (25 11.6), M2 (31 11.1), M3 (35 13.7), and M4 (45 6.8). AST iu/l in C (20 4.2), M1 (32 11.2), M2 (35 8.5), M3 (41 11.2), M4 (54 9.8). ALP iu/l in C (78 13.5), M1 (92 14.7), M2 (86 15.2), M3 (93 22.0), M4 (100 14.0). T. Bilirubin mg/dl in C (0.54 0.15), M1 (0.99 0.32), M2 (1.2 0.37), M3 (1.7 0.75), M4 (2.1 0.53). D. Bilirubin mg/dl in C (0.22 0.10), M1 ( 0.32 0.13), M2 (0.46 0.21), M3 (0.80 0.48), M4 (0.77 0.19). Ind. Bilirubin mg/dl in C (0.31 0.10), M1 (0.67 0.26), M2 (0.82 0.29), M3 (0.96 0.33), M4 (1.3 0.39). T. protein g/dl in C (7.4 0.38), M1 (7.2 0.44), M2 (7.1 0.29), M3 (6.9 0.34), M4 (6.6 0.44). Albumin g/dl in C (4.2 0.38), M1 (3.8 0.31), M2 (3.4 0.50), M3 (3.4 0.46), M4 (3.4 0.38). Globulins g/dl in C (3.1 0.32), M1 (3.3 0.48), M2 (3.6 0.53), M3 (3.5 0.47), M4 (3.2 0.34). We found that there was significant increase in AST, ALT, ALP, Total, Direct, Indirect Bilirubin in all malaria patients compare to controls with p-value 0.05 and there was significant decrease in total protein and albumin in patients comparing to controls with p-value 0.05 except in T. Protein group M1 there is no significant difference when comparing to control group with p-value.075.