Comparison of Efficacy of Oral Hypoglycemic Agents in Diabetic Patients

Diabetes is a group of metabolic disorders characterized by persistent hyperglycaemia resulting from defects in insulin secretion, insulin action, or both. Besides symptoms related to hyperglycaemia itself such as thirst, polyuria and weight loss, it may also cause potentially life-threatening acute hyperglycaemic emergencies. With good control of hyperglycemia established early on and continued life-long, an individual with diabetes can enjoy a good quality of life and reduce the risk of these long-term complications that are so detrimental to their life and wellbeing. The Objective of the study is to compare the efficacy of anti-diabetic agents among type-2 diabetic patients. A total of 60-80 male and female patients with type-2 diabetes are selected and patients are randomly divided into groups based on their disease and treatment. Efficacy of medications with respect to patient demographics such as age, weight and gender are compared. Patients with the age ranging from 40-70 years are taken into study. In our study vildagliptin with metformin showed greater reduction of fasting and post-prandial blood glucose levels when compared to pioglitazone and glimeperide combinations. No weight gain is reported in patients using vildagliptin and only mild hypoglycaemic episodes are reported in some patients. Our study concludes thatVildagliptin combination is more effective in controlling fasting and post-prandial blood glucose levels when compared with pioglitazone and glimeperide combinations.