Ultrastructural Pathology of Paraquat (PQ) Induced Acute and Subacute Lung Injury in Experimental Rats

Paraquat (PQ) is a widely used herbicide throughout the globe, which induces acute lung injury (ALI) in rats. Studies on acute and subacute lung injury due to PQ toxicity at different doses through different routes are sparse. Microscopically (LM and EM) a noteworthy changes like proliferation of fibrous tissue into lung parenchyma and also in liver and mild to moderate changes kidney. Significant alterations in body weights and haematobiochemical parameters were also documented in acute (24, 48, 72 hrs) and subacute (7, 14, 21 days) study in male Wister rats.