The Effect of Physical Exercise on Ovarian Follicles of Perimenopausal Wistar Rats

Background Aging is accompanied by a progressive loss of the functional unit of the ovary, the follicle. A decrease in the number of follicles that are the source of ovarian hormones causes irregularities of the hormonal system. Physical exercise has been recognized by society is very important and inseparable from physical and psychological health. Objective The main purpose of this study was to examine the effect of physical exercise on the ovarian morphology of perimenopausal wistar rats. Method This research was conducted at Biomedical Integrated Laboratory of Medical Faculty of Udayana University and Pathobiology Laboratory of Veterinary Faculty of Udayana University in June until November 2016, using 12 female Wistar rats aged 14 months divided into 2 groups, a sedentary control Group (SC) and a trained experimental group (T). The treatment group was given physical exercise to swim for 30 minutes 5 times a week for 30 days. Result The results showed that the average number of primary follicles, secondary follicles, and tertiary follicles in the T group group was significantly higher (p less than0.05) than the SC group. The atresic follicle in the T group was significantly lower (pless than0.05) than the mean number of atresic follicles in the SC group. Conclusion this study demonstrates that physical exercise improves ovarian function in perimenopausal wistar rats.