Cytological Diagnosis of Body Fluids and Fine Needle Aspirates-Correlation between Cytospin Method and Cell Block Preparation, at a Tertiary Centre

Diagnostic cytology is a science based on three basic sampling techniques- Collection of exfoliated cells, Collection of cells removed by brushing or similar abrasive technique, Aspiration biopsy or removal of cells from non - surface bearing tissues by means of needle with or without a syringe. Method Patients were diagnosed by clinical history, lab tests,& cytological examination by cytocentrifuge and cell block technique as and when required. Fixative was usually not added because ethanol the usual cytological fixative causes heavy precipitation of proteins which interferes with concentration of cells. Conclusion It is thus concluded from the present study that it is advisable to study by both cytospin and cell block method before discarding specimens that are negative for malignant cells by smear examination.