Study of Relation of Lactate Dehydrogenase Levels with Severity of Preeclampsia and its foetal Outcome

Background Pre eclampsia is a multisystem disorder characterized by vascular endothelial dysfunction. Elevated levels of LDH indicates cellular damage and can be used as a biochemical marker to reflect complications and fetal outcome. Aim To analyse the severity of preeclampsia and evaluate the outcome of baby by raised LDH levels. Material and methods 100 patients with high blood pressure after 28 weeks of gestational age were included. The diagnosis of severe pre-eclampsia was made when a diastolic blood pressure was measured 110 mmHg on two or more occasions, or 120 mmHg on one or more occasions, in the context of significant proteinuria (300 mg/24 hours, or persistent 1+ on dipstick). Serum LDH level was done twice weekly. A baseline ultrasound was performed. Reversed end-diastolic flow was an indication for delivery. Observation and results In severe preeclampsia group 40 % patients had LDH levels greater than800 IU/L 50 % of babies had low birth weight with maternal serum LDH levels 600 IU/L. Conclusion Raised LDH levels can predict the occurrence of maternal and neonatal complications.