NT-pro CNP Level Estimation; Its Experimental and Clinical Relevance

C type natriuretic peptide is an important member of the natriuretic peptide family. A-type and B-type natriuretic peptides are established markers in chronic heart failure (HF). C-type natriuretic peptide. (CNP) belongs to the same peptide family, but is predominantly localized in the endothelium. The prognostic role of CNP and its N terminal metabolite in various disorders has not been totally established. The widespread increase of CNP secretion in multiple tissues across the brain in response to dexamethasone implicates CNP and the NT- pro CNP in glucocorticoid actions possibly related to inflammation or local fluid dynamics mediated by glial cells. These findings pave the way for future studies designed to establish the role of CNP and NT-pro CNP in the CNS in normal health in vivo, and to establish a clinical application for this peptide in pathophysiological disorders in the CNS. The aim of the study is to evaluate the clinical correlates of the N-terminal part of pro CNP in various disease states and in experimental conditions.