Correlation of Immunoexpression of E-Cadherin and Vascular Endothelial Growth Factor to Histopathology Gradation and Enlargement Regional Lymph Node in Oral Squamous Cell Carcinoma

Introduction. Oral Squamous Cell Carcinoma (OSCC) is the most common factor of secondary infection in the head and neck. Changes in the expression function of both E-Cadherin and Vascular Endothelial Growth Factor (VEGF) genes are known to provide an increased chance of invasion, metastasis and tumor growth. Immunohistochemistry immune techniques are known to examine the expression of tumor-linked gene proteins (immunoexpression) with a high degree of cellular accuracy. Method. A total of 30 body tissue subjects were selected from patients of Anatomical Pathology Faculty of Medicine Universitas Padjadjaran-Hospital Dr. Hasan Sadikin Bandung. Subsequently prepared using immunohistochemistry principles to test the correlation of histopathology gradation and immunoexpression of both E-Cadherin and VEGF. This cross sectional study with secondary data was retrospective and then evaluated correlation of both immunoexpressions of E-Cadherin and VEGF. Correlation using Correlation Rank Spearman with significance p less than0, 05. Results. There was a negative correlation (rs=-0.522) and significant (p less than0.005) between E-Cadherin and histopathology gradations of OSCC. Results also showed no significant correlation between immunoexpression of both E-Cadherin and VEGF to enlargement of lymph nodes regional of OSCC. Conclusion. Oral Squamous Cell Carcinoma. Either E-Cadherin or VEGF is unrelated in enlargement of regional lymph nodes of Oral Squamous Cell Carcinoma.