TNF-? Receptor 1 Promoter Gene Polymorphisms and Susceptibility to Gastric Cancer Related to H. Pylori Infection in Moroccan Population

Helicobacter pylori (H. pylori) infection is the main cause of serious gastric illness such as gastric cancer (GC). Single nucleotide polymorphisms (SNPs) that affect immune response genes may influence the host inflammatory reactions, then the development of diseases. To date, no reported studies investigated the relationship between Tumor Necrosis Factor receptor 1 (TNFR1) gene polymorphisms (-383, 580 and 609) and the development of gastric cancer. The aim of this study is to evaluate the involvement of TNFR1 SNPs in the development of chronic gastritis and GC, in Moroccan population. In total 265 patients and controls were selected for the study. Three polymorphisms of promoter gene TNFR1were researched in all subjects. The analysis of polymorphisms revealed the entire absence of TNFR1 -383 (A/G) SNP in our population, and no significant difference of allele distributions of TNFRSF1 -580 (A/G) was observed between GC, Chronic gastritis and Healthy Controls. While, the proportion of individuals carrying the TNFR1 -609 T allele was significantly lower in GC group than in controls group. These results suggest that the TNFR 1 -609 T allele has a protective function against GC.