Design ? Syntheses, Characterization and Evaluation Antimicrobial Activity for Some azobenzen-p, p-disubstituted with (3, O), (3, N-) substitute, (3, H) -quinazolin-4-one-2yl and 4-substituted quinazolin-2yl moieties

Two of 3, O-substituted quinazoline-4-one namely azobenzen-p, p'-di [3, O-benzyl-4 (3H)quinazolin-4-one-2yl], and azobenzen-p, p'-di [3, O-acetyl-4 (3H)quinazolin-4-one-2yl], were synthesized from azobenzen-p, p'-di [3-hydroxy-4 (3H)quinazolin-4-one-2yl]. Two of 3-N-substituted quinazoline-4-one namely azobenzen-p, p'-di [3, N-benzensulphonylamide-4 (3H)quinazolin-4-one-2yl], and azobenzen-p, p'-di [3, N- (4'-nitrofurfurylidine-2'-yl imino)-4 (3H)quinazolin-4-one-2yl], were synthesis from azobenzen-p, p'-di [3-amino-4 (3H)quinazolin-4-one-2yl]. azobenzen-p, p'-di [3-hydro-4 (3H)quinazolin-4-one-2yl], was synthesized from azobenzen-p, p'-di (3, 1-benzoaxzine-4-one-2yl], which was used for synthesis azobenzen-p, p'-di [4-chloro-quinazolin-2yl], while its treatment with p-toluidine and ethylene diamine give azobenzen-p, p'-di [4-N-toludino-quinazolin-2yl], and azobenzen-p, p'-di [4-N-aminoethylamine-quinazolin-2yl] respectively. All synthesized compounds characterized by FTIR, 1HNMR, 13CNMR and mass spectral analyses. All synthesized compounds, were examined as antibacterial agents against gm (+ve and ?ve) bacteria, and antifungal agents. Results showed abroad extended excellent to moderate effects as antibacterial and antifungal agents.