Synthesis of Bis-Heterocyclic Compounds and Study their Antimicrobial Activity

According to our recent previous published work, new series of triazole based Schiff's bases (6a-j) have been synthesized from the reaction of benzaldehyde derivatives. Characterization of the synthesized bis-heterocyclic compounds was achieved by 1H NMR, 13C NMR, and FT-IR spectroscopic methods. The antimicrobial activity of compounds 5, and 6a-j were studied against a gram negative bacteria (Escherichia Coli) and a gram positive bacteria (Staphylococcus Aureus). As expected, results revealed that most of studied compounds display high antibacterial activity against both kinds of bacteria, especially against Escherichia Coli. Generally, the antbacterial activity increased with increasing compound concentration and most synthesized compounds can be considered as antibacterial agents even better than the reference in the case of Escherichia Coli. Particularly, synthesized Compounds 5, 6f, and 6j have been indicated as the most effective candidates against Staphylococcus Aureus, while the highest antibacterial activity against Escherichia Coli have been revealed by compounds 6e, 6f, and 6j. In this study it was found that antibacterial activity of synthesized compounds is proven firstly by the bis-heterocyclic character and secondly by variation of benzene ring substitution.