Oral findings, Oxidative Stress and Antioxidant Biomarker Assessment in Serum and Saliva of Crohns Patients

Background Crohn's disease (CD) is a transmural inflammatory disorder of any part of alimentary tract, mostly associated with the interaction of environmental risk factors and immunological disturbances to normal microbiota of the intestine. However in the recent year it has been proposed that oxidative stress as a result of immunological factors over activation was highly suggested to be one of the major pathological mechanisms of Crohn's disease. The natural cores of CD is fluctuate by periods of remission and flare up and associated with various intestinal and extra intestinal symptoms. Subjects, Materials and Methods We aimed to compare the level of oxidative stress and antioxidants capacity in serum and saliva of fifty patients with moderate to sever Crohn's disease and twenty five control subjects by assessing lipid peroxidation Malondialdehyde (MDA) and antioxidant glutathione (GSH) markers. Blood and saliva samples were collected and salivary flow rate was measured for control subjects and Crohn's patients. Body mass index (BMI) was determined by dividing the weigh (kg) by length (m2) for all participants. Results The mean of BMI of Crohn's patients showed non significant difference (pgreater than0.05) than control subjects, while Crohn's patients showed highly significant reduction (p