Comparison of Haemodynamic Profile of Thiopentone and Etomidatein to Pressor to Laryngoscopy and Intubation

Aim and Objective- To quantify and compare cardiovascular response to direct laryngoscopy and endotracheal intubation using intravenous Thiopentone sodium and intravenous Etomidate. Materials and methods- This study was carried out in the Department of anesthesiology, Acharya Vinoba Bhave Rural Hospital, affiliated to Jawahar Lal Nehru Medical College, Sawangi (Meghe), Wardha. This study comprised of 100, ASA I and II patients who were randomly allocated into two groups of 50 each - Etomidate Group (E) and Thiopental Sodium Group (T). Result- At laryngoscopy and 1 min after intubation, PR increased significantly in both the groups. Increase was significantly more in Group T than in Group E. At 4 minute after intubation, increase in PR was significantly greater in Group T than in Group E. At 5 minutes, PR decreased in both the groups, difference being statistically significant. SBP, DBP, MAP and RPP decreased significantly after induction and intubation at 1, 2, 3, 4 and 5 min in Group E than in Group T. Conclusion- Inj. etomidate at 0.3mg/kg has a better haemodynamic profile as compared to inj. Thiopentone sodium in attenuation of pressor response to laryngoscopy and endotracheal intubation by significantly suppressing sympatho-adrenal reflex activity.