To Analyze the Impact of Prognostic Factors on Remission Induction in Acute Lymphoblastic Leukemia-A Tertiary Care Centre Study

Objective To analyze the impact of prognostic factors on remission induction in acute lymphoblastic leukemia-A tertiary care centre study. Study Design Prospective and Cohort. Place and Duration of Study Aga Khan University Hospital, Karachi, data collected from March 2005 to February 2006. Materials and Methods 36 patients were evaluated to analyze the impact of prognostic factors on remission status after receiving 04 weeks of induction chemotherapy. Patients with acute lymphoblastic leukemia of all ages and gender were included and all other lymphoproliferative disorders, refractory and relapsed acute lymphoblastic leukemia were excluded in the study. A proforma was filled for each patient at the time of presentation. These patients were followed at the end of induction chemotherapy and remission status is assessed by bone marrow examination. Tests Performed on the Blood Samples. Chi-square test was applied to determine the significance. The P value 0.23). Although more cases were found in remission among ages between 1-20 years but the result was not statistically significant probably due to sample size. The remission is dependent of WBC count with a cutoff range 50x109/L (P0.23) and regarding immunophenotyping the remission is independent on immunophenotype seen on flow cytometry (P