Role of Antioxidants on Thyroid Hormones in Wister Rats

It is estimated that huge amount of ROS, especially of H2O2, are produced in the thyroid under physiological conditions, justifying the statement that the thyroid gland is an organ of oxidative nature. The present research work aimed to investigate the free radical scavenging activity, lipid peroxidation and antioxidant status in both hyperthyroid and hypothyroid patients. Adult male Wister rats, weighing around 150-200 gms used in this study. Rats were maintained in the animal care facilities. Under veterinary supervision, food and water were supplied ad labium to the animals. All rats were fed with normal diet (20 % protein). Animal studies were performed in compliance with generally accepted guidelines governing such work. Rats have been administered with known amount of Vitamin C, Vitamin E and turmeric. Results showed increased levels of thyroxin in rats after 15 days. ( Vit C-5.2 1.2 NS, Vit E - 5.3 0.5 NS and Turmeric-5.3 0.87 NS)