Synthesis, Characterization and Microbial Activities of Novel Acetylthiophene Chalcone Derivatives

Synthesis of Chalcones from acetylthiophene with substituted aromatic aldehyde in dilute ethonolic sodium hydroxide at cool condition reaction followed by Claisen Schmidt condensation method. The resulting compounds were characterised by IR, 1HNMR, 13CNMR spectral studies and elemental analysis. The synthesized compounds were screened for their antibacterial and antifungal activities by disc diffusion method. The antibacterial and antifungal activity was evaluated against Klebsiella aerogenes, Proteus Vulgaris, Mucor racemosus, Aspergillus flavous and Aspergillus fumigatous (fungal strain) using Ciprofloxacin and Nystatin as the standard drug for bacteria and fungus respectively. The preliminary in antibacterial and antifungal screening of the chalcone derivatives PI PV compounds showed potent activity.