Hydro-alcoholic Extracts of Fagonia indica Burm. f. Contribute Anti-pyrexia Activity to E. coli Exposure in Rabbits

Folk herbal practitioners of the Cholistan desert claim antipyretic activity in Fagonia indica Burm. f. . To validate the claim of local herbal practitioners, hydroalcohalic extract of aerial parts of Fagonia were orally tested at 25mg/kg, 50mg/kg and 100mg/kg of body weight for antipyretic effect in E. coli induced pyrexia in rabbits. As compared to the negative and positive control groups the dose rate 100mg/kg showed high antipyretic activity followed by the dose of 50mg/kg and 25mg/kg body weight. The results of present study leads to conclude that the hydro-alcohlic extract of Fagonia cretica have significant antipyretic activity. These results also affirm the claim by the local herbal practitioners of the region which use this plant to cure fever in humans.