Blood Coagulation Changes among Sudanese Patients with Pulmonary Tuberculosis

Objective: To assess the blood coagulation changes in patients with Pulmonary Tuberculosis (PTB). Methodology: Fifty Patients with PTB were included in this study, in addition to 10 apparently healthy individuals as internal control group. Coagulation parameters of prothrombin time (PT), activated partial thromboplastin time (APTT), (TT), Platelet count, Hb concentration and ESR were measured in each patient. Results: The mean values for coagulation measures for cases compared to controls were 15.4 1.9 compared to13.4 0.5 for PT (P less than 0.002), 34.34.7 compared to 30.2 6.5 for APTT (P less than 0.02), 13.41.5 compared to 13.1 0.9 for TT (P less than 0.6), 384, 500 153, 000 compared to 259, 400 94, 000 for platelets (P less than 0.001), 11.2 1.7 compared to 13.6 1.6 for HB (P less than 0.001) and 75.7 26 compared to 16 9 for ESR, respectively. Conclusion: PTB is associated with prolongation of PT, APTT, thrombocytosis, anemia and elevated ESR.