In-Vivo Wound Healing Activity of Silver Nanoparticles: An Investigation

Nanotechnology is an emerging field, with enabling technology, the creation and application of materials, devices, and systems at atomic and molecular levels. Medicinal use of nano-silver is claimed to have reduced side effects and enhanced therapeutic activity as compared to ionic counterpart (silver ions). The use of noble metal nanoparticles as drug carriers presents principal advantages, they are able to transport several therapeutic molecules adsorbed on their surface. The current research activities synthesized the silver bio-nanoparticles from Penicillium chrysogenum by intracellular method. The morphological studies of the biosynthesized nanoparticles are done using UV-visible spectrophotometer, SEM,& FTIR techniques. After formation of silver bio-nanoparticles (Ag-NPs), they were tested against different pathogenic organisms like Pseudomonas aeruginosa, Bacillus cereus, E. coli, and Staphylococcus aureus. The highest sensitive antimicrobial activities were observed in Staphylococcus aureus followed by E. coli, Pseudomonas aeruginosa and Bacillus cereus. The research also includes the comparative study of the nanoparticle with the standard drug in healing wound of a rat. The results showed that the day of healing was less in silver nanoparticles when compared to other standard drug.