Effect of Glycerin as Plasticizer in Orodissloving Films of Losartan Potassium

The preparation of orodissovling films of Losartan Potassium with the purpose of developing a dosage form for a very quick onset of action, which is very convenient for administration, without the problem of swallowing and using water. Losartan Potassium is antihypertensive agent, antagonist of angiotensine.2. The Films of Losartan Potassium were prepared by using polymer as HPMC 15 Cps, Glycerin as plasticizer, polysorbate 80 as a surfactant, sodium saccharin as a sweetening agent, Menthol as a flavoring agent, ethanol as preservative by solvent casting method. The fast dissolving oral films were designed using optimal design and numerical optimization technique was applied to find out the best formulation. The formulated orodissolving films were evaluated for physical characteristics such as thickness, Folding endurance, drug content uniformity, percentage elongation, gave satisfactory results. The formulations were subjected to disintegration, In-Vitro drug release tests. The marked increase in the % drug release was exhibited by mouth dissolving firms of Losartan potassium containing HPMC 15 cps as a polymer at 15 min. , orodissolving films of Losartan potassium shows 84.29 drugs release at 15 min. orodissolving films of Losartan potassium F3 Formulation (Containing 14 % glycerin) shows percent elongation 25, folding endurance 32, disintegration time 28.15 sec, thickness 0.09 mm and % content uniformity 81.4 %.