Formulation and Evaluation of Simvastatin Solid Dispersion Tablets

The purpose of the study is to improve the dissolution& stabilization of simvastatin, a poorly water soluble drug by solid dispersion. Simvastatin belongs to BCS class 2 having low solubility& therefore low oral bioavailability (5 %) 3. the solid dispersions is prepared by kneading method us using carriers at different drug carriers ratio (pvp-k30). The characterization of solid state properties of pure simvastatin is done by using FTIR. The formulation of simvastatin is done by direct compression method. The evaluation of formulated simvastatin is done by using physiochemical parameters such as hardness, friability, weight variation, uniformity of drug content& In vitro dissolution time.