A Case Study of Drug Induced Acute Interstitial Nephritis with combined use of Beta-Lactams, NSAIDs and Amikacin

The process of wound healing in crush injuries would concede long period due to the large open wound. During this period, the subject will be on antibiotics as a prophylactic therapy to prevent infection and analgesics to relieve the pain for patient comfort. Long-term use of antibiotics (Beta-lactams and Amikacin) and analgesics (NSAIDs) can degrade the functioning of renal organs. Acute Interstitial Nephritis is an entity of Acute Kidney Injury which is manifested mostly with the use of nephrotoxic drugs rather than microbes. This article presents a case of Acute Interstitial Nephritis with the combined use of Amikacin, NSAIDs and Beta-lactams in inpatient who has admitted due to crush injury.