Effects of Acute and Chronic Lead Exposure on Kidney Lipid Peroxidation and Antioxidant Enzyme Activities in BALB-C Mice (Mus Musculus)

Extensive and unmonitored use of lead in developing and industrialised countries is posing a serious threat to human health. Prolonged exposure of a sub-lethal dose of this toxicant is closely related to its accumulation in various soft tissues and its interference with bio elements that hamper several physiological processes. Present study was carried out to investigate the toxic effects of lead acetate on biochemical parameters in the kidney of Swiss-albino mice with a trial to evaluate their self recovery from this toxicant in respective parameters without any supplement. Therefore eighteen normal mice showing no sign of morbidity were divided into three groups of 6 animals each. Lead acetate was given orally to mice for 40 days. First group served as control and was given normal saline solution as vehicle. Mice of second group were given daily 10mg/kg bw of lead. Whereas third group was given daily 150mg/kg bw of lead. The mice of both the groups were sacrificed by cervical dislocation after day 1, 40 and 80 along with control animals. The findings indicated that exposure for 40 days resulted in significant increase (p