Some peculiarities of carbohydrate metabolism in the cornea and correction of its disturbances in modeled alkaline burn of the cornea
Journal: Oftalmologicheskii zhurnal (Vol.2014, No. 2)Publication Date: 2014-04-20
Authors : CHALANOVA R.I.; PARKHOMENKO T.V.; MBARKI M.;
Page : 92-96
Keywords : EYE BURNS; LACTATE; PYRUVATE; CYTOFLAVIN;
Abstract
Introduction. On the basis of the content of the substrates of glycolysis of pyruvate and lactate in the burnt cornea the conclusion may be made about the way of realization of the tissue respiration in the eye burn and efficacy of using cytoflavin with the antihypoxic aim. Purpose of the study. To reveal disorders of the anaerobic-aerobic phases of the carbohydrate oxidation in the burn trauma of the cornea (by the level and ratio of lactate and pyruvate) and possibility of the correcting influence of cytoflavin on the pathochemical processes. Materials and methods. The study was made in both eyes of 20 rabbits with modeled severe alkaline burn. The controls were intravenously introduced 2.5 ml of the physiological solution from 10 to 14 days; the main group was introduced 0.5 ml of cytoflavin and 2.0 ml of the physiological solution. The cornea was taken for the biochemical investigation on the 3rd, 7th, 21st, 30th and 45th day. Results. The data obtained are evidence of disorder of the aerobic type of the tissue respiration. The application of cytoflavin contributes to improvement of the course of the pathochemical processes in the burnt cornea. The difference in the pyruvate and lactate content on the 45th day of the burn process was 1.5 % in the main group of animals and 10 % - in the controls. Conclusion. There was established suppression of the aerobic phase of the carbohydrate metabolism and improvement of its indices after the application of intravenous injections of cytoflavin with the antihypoxic aim.
Other Latest Articles
- Possibility of metabolic correction of the functional condition of mitochondria in the retina in different periods of development of experimental diabetes
- Peculiarities of the morphological changes of chorioretinal complex in rabbit eyes after exposure to high-frequency electric current with a frequency of 66 kHz (modified generator EC300 - Ml)
- Experimental research of the influence of seven-day tamponade with perfluorine-organic compounds on the ultrastructure of the rabbit eye
- The study of efficacy of in layer transplantation of heterogenous transplant of the cornea equivalent in the experiment
- Efficacy of using the drug Amixin in complex treatment of patients with uveal melanoma in reduction of lymphocyte content
Last modified: 2015-01-20 21:54:20