Effects of Kyotorphin and D-Kyotorphin on Pain Perception and Blood ACTH and Corticosterone Concentrations after Heat Stress in Rats
Journal: International Journal of Science and Research (IJSR) (Vol.3, No. 11)Publication Date: 2014-11-05
Authors : Adriana Bocheva; Hristina Nocheva; Dimo Krastev;
Page : 2254-2259
Keywords : Kyotorphin; D-Kyotorphin; Heat stress; Nociception; Anti-stress system;
Abstract
Aims& Objectives: The present study consists in evaluation of the effects of the dipeptides Kyotorphin (Kyo) and D-Kyotorphin (D-Kyo) on nociception and plasma levels of adrenocorticotrophic hormone and corticosterone after 1 hour of heat stress in rats. Materials& Methods: Kyo and D-Kyo`s effects on nociception were evaluated by Paw pressure and Hot plate test after 1 hour of heat stress. Plasma levels of both hormones were determined by Radio immunological assays. Conclusions: Since a decrease in heat-stress-induced analgesia and ACTH and CORT plasma levels was observed we assumed that both dipeptides take part in the body`s anti-stress system.
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