Study of Serum Ferritin as a Component of Metabolic Syndrome

Background: The metabolic syndrome (Syndrome X, Insulin resistance syndrome) consists of constellations of symptoms of central obesity, hypertriglyceridemia, low HDL cholesterol, hyperglycemia, and hypertension. Elevated serum ferritin levels independently predicted incident type 2 diabetes in prospective studies in apparently healthy men and women. In cross-sectional studies, elevated ferritin levels have been associated with hypertension, dyslipidemia, elevated fasting insulin and blood glucose and central adiposity. Aims and Objectives The present study was done to determine the association of serum Ferritin in Metabolic Syndrome as well as to determine the relation between individual component of metabolic syndrome& number of components of metabolic syndrome and plasma ferritin. It is a Correlational clinical single group study Results: In the present study, there were 99 males& 51 females with mean Age distribution of 57.358.03. The majority of patients (40 %) were in their sixth decade of life. Mean BMI in our study was 29.391.78, with 96 (64 %) of patients meeting criteria for central obesity, according to NCEP ATP3 guidelines. In our study 126 (84 %) of patients had a blood pressure recording of more than 135/85mmhg. Ninety nine patients (66 %) were known hypertensives about treatment.117 patients (78 %) were known diabetics on treatment, 33 (22 %) patients did not have a history of diabetes. In our study 77 (51.33 %) patients had abnormal total cholesterol (greater than200mg/dl), 108 (72 %) patients had abnormal triglycerides (greater than150mg/dl), 113 (75.33 %) patients had abnormal HDL (50 in females) There were 53 (35.3 %) patients with 3 components of metabolic syndrome, 57 (38 %) with 4 components and 44 (29.33 %) with 5 components of metabolic syndrome. The present study revealed that Serum ferritin was increasing significantly with increasing number of components of metabolic syndrome with P=0.052. It also showed that individual components of metabolic syndrome had significant correlation with increasing number of components of metabolic syndrome. Central obesity was increasingly associated with increasing number of metabolic syndrome with a significant p value of