Triple Combination Therapy ? A 12 Month Case Series

The ultimate goal of periodontal therapy is complete regeneration of the periodontal attachment apparatus. The combination of various regenerative biologic agents has recently attracted the interest of researchers in the field of reconstructive periodontal surgery. The role of polypeptide growth factors in periodontal regeneration has been documented through animal and human studies. In the last decade, platelet rich plasma (PRP) has been used for its potential in delivering growth factors in intrabony defects. Platelet-rich-fibrin (PRF) is second generation platelet that has several advantages over the traditionally prepared PRP.10 patients with chronic Periodontitis presenting grade III furcation involvement were included in the study. The following clinical parameters were evaluated prior to treatment and after 6 and 12 months vertical probing depth, horizontal probing depth and clinical attachment level at the furcation site. The post operative healing was uneventful in all cases, and no complications were observed throughout the entire study period. At 6& 12 months, out of the 10 cases in our case series 8 cases only showed complete closure of furcation involvement had occurred and improvement in vertical& horizontal probing depths and gain in clinical attachment level, were as 2 cases showed partial closure and minimal gain in clinical attachment level. The purpose of this case series was to evaluate the effect of combining bonegraft, guided tissue regeneration (GTR) and Platelet rich fibrin (PRF) in the surgical treatment of grade III mandibular furcation involvement. This paper reports the use of triple combination therapy which has been shown to be effective in promoting clinical signs of periodontal regeneration.