Systemic Inflammations in Non Obese and Obese Uncontrolled Asthma

Background. Asthma is a chronic airway inflammation. There is increasing evidence confirming in severe or persistent asthma systemic inflammation can occur. Spillover of inflammatory mediators into the circulation is generally considered to be the source of this systemic inflammation. Obesity is well known to be associated with systemic inflammation too. Both asthma and obesity often occur in the same individual. We examined the independent and synergistic associations of asthma uncontrolled and obesity with systemic inflammation using high-sensitivity C-reactive protein (hs-CRP). Methods. This was an observational study with cross-sectional approach in 48 asthma subjects with aged 18 55 years old without diabetes, cardiovascular disease, hypertension and non smoker. The study was performed in the Hasanuddin Teaching Hospital South Sulawesi Indonesia. Asthma control was assessed using asthma control test (ACT). Results Mean of hs-CRP levels were significantly higher in uncontrolled asthma than controlled asthma (4.23 + 3.11 vs 0.92 + 0.61, p=0.001). The high hs-CRP levels were most found in uncontrolled asthma patients than controlled asthma. Obese Subject with uncontrolled asthma have higher hs-CRP levels compared to obese subject with controlled asthma (p=0.026). In non obese subject with uncontrolled asthma have also siginificant higher hs-CRP compared to non obese controlled asthma (p=0.005). Hs-CRP level significantly higher in uncontrolled asthma both in obese and non-obese subject. Hs-CRP levels in asthma subject were not influenced by age (p=1.000), gender (p=0.822), family history of asthma (p=0.117), long duration of asthma (p=0.117) and used of steroid. (p=0.358). Conclusion Uncontrolled Asthma associated with systemic inflammation both in obese and non obese subject. These findings underline a potensial CVD risk in asthma especially with uncontrolled status.